The INLIGHT interim readout reported a 14.3% placebo-adjusted reduction in visceral fat six months after a single dose, alongside preservation of lean muscle mass - a differentiated profile compared to GLP-1 therapies that often reduce muscle alongside fat.
It's not simply the accrual of excess fat that leads to disease. It's a change in the actual function and the capacity of the energy center within the cell to work properly. The circadian rhythm is the body's own internal 24-hour clock that regulates the sleep-wake cycle, hormone levels and metabolism, among other systems throughout the body.
Most of the carbohydrates in these foods - as well as most of the calories - come from starch, of which there are two types: hard-to-digest amylose and easily digested amylopectin. The latter is processed quickly and spikes blood sugar. The former is processed slowly and moderates blood sugar.
Here, in the omphalos of the newly-minted Commie Corridor was a display of cultural force every bit as robust as the political one which had recently vaulted socialist Zohran Mamdani to the Democratic nomination (and, in short order, the mayoralty). So why, then, as the Rochdale duo took the stage in their preferred semi-darkness, was the atmosphere cut with an unmistakable current of dread?
Just 10 minutes of intense exercise can flip genetic switches that help stop bowel cancer in its tracks. Credit: Shutterstock As people return to gyms or start new fitness routines in the new year, new research suggests that even a short burst of intense exercise could play a role in protecting against cancer. Scientists report that as little as 10 minutes of hard physical activity may help slow cancer growth.
There's a particular kind of winter quiet that settles in around January - a soft, heavy stillness that seems to press itself against windows that look out into a muted world of dull skies and bare branches. The idea of stepping outside feels like far more effort than it should. Inside, the air feels warmer, and my home becomes a nest made of cozy blankets, soft lamplight, and familiar corners.
There's a glorious smugness that can only be experienced by exercising outdoors in winter conditions. The fresh air, the endorphins, the reduced risk of heart disease they're all nice bonuses, but nothing beats that knowing nod from another rain-drenched runner, or the horrified faces of nearby dog walkers as you stride confidently into the sea for a winter dip.
Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and auxiliary lipids facilitating transfer remain unknown. We have combined biochemical, lipidomic and computational methods to systematically characterize LTP-lipid complexes4 and measure how LTP gains of function affect cellular lipidomes. We identified bound lipids for approximately half of the hundred LTPs analyzed, confirming known ligands, while discovering new ones across most LTP families.
Don't put all your eggs in one basket when it comes to exercise - doing a variety of different physical activities every week is the key to boosting your health and living longer, a study suggests. After tracking the weekly exercise habits of 110,000 men and women in the US for 30 years, researchers found active people who did the greatest variety of exercise were 19% less likely to die during that time than those who focused on one activity. That effect was greater than for individual sports like walking, tennis, rowing and jogging. The total amount of exercise you do is still key, experts say, but doing a range of activities you enjoy can bring lots of benefits.
Rather than simply extending the fasting window or cutting more calories, the intervention group was simply asked to finish eating at least three hours before their usual bedtime. That meant no snacking while watching TV after dinner and no "just one more bite" at 10 p.m. (my personal downfall). This relatively simple intervention ensured that the overnight fast overlapped with the body's natural sleep-wake rhythm.
After 10 years of jogging, I officially ran out of steam. As much fun as I had finishing my first marathon in 2024, the training burned me out. In the months that followed, I had no desire to hit the track near my home, let alone sign up for another race. Plus, my go-to running buddies and I all moved, making running a more solitary and, frankly, boring activity. While I could join a new local run club, I resisted.
"As we get older, the immune system is shifting away from good inflammation," which is the body's short-term, acute response to fend off injury or infection and promote healing, explains Dr. Thomas Marron, one of the researchers leading the new study. Marron directs early phase clinical trials at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai.
When we say we want to lose weight, we typically mean shedding fat but not muscle. Muscle helps us to look "toned" and supports our metabolism. To lose fat without losing muscle, eat enough protein and strength train regularly, two top trainers said. If you want to lose fat without losing muscle, there are three things you need to know.
A Colorado endocrinologist helped spark a quiet revolution in weight care by changing how primary care clinics talk about - and treat - obesity. Instead of vague advice to "eat less and exercise more," a new system called PATHWEIGH gave patients a clear, judgment-free path to real medical support for weight management.
