Eberflus, 55, was the defensive coordinator in Indianapolis from 2018-21. The Colts ranked in the top 10 in takeaways in each of his four years there and will likely be a primary focus of his job with the 49ers.
But the Colts still will have some upheaval in the months to come. Although the idea that the Colts are "running it back" has taken hold in recent weeks, there remains the possibility of significant changes. Critical areas from the offensive line to the defensive front seven could be significantly impacted by offseason moves that might require some getting used to. The Indianapolis roster is bound to look different in 2026.