More than 17,500 patients are living on the waiting list at any given time for a liver transplant. Unfortunately, there aren't enough of the available, donated organs to go around, leading to a critical and frequently deadly backlog. Roughly 10% of the patients on that waiting list die each year while waiting for the prospect of a new organ.
Sorbitol can be metabolized into fructose in the liver, directly linking its consumption to the same harmful pathways that cause fatty liver disease and metabolic dysfunction. This discovery forces a sobering reevaluation of the artificial and alternative sweeteners millions consume daily in an effort to live healthier lives.
Most of the carbohydrates in these foods - as well as most of the calories - come from starch, of which there are two types: hard-to-digest amylose and easily digested amylopectin. The latter is processed quickly and spikes blood sugar. The former is processed slowly and moderates blood sugar.
As hormones shift during the transition into menopause, many women notice that their energy levels react differently to carbohydrates than they did in earlier years. Muscle mass tends to decline with age when strength training is absent from a routine. Because muscle mass determines how the body uses glucose, maintaining it through regular activity may support steadier daily energy.
Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and auxiliary lipids facilitating transfer remain unknown. We have combined biochemical, lipidomic and computational methods to systematically characterize LTP-lipid complexes4 and measure how LTP gains of function affect cellular lipidomes. We identified bound lipids for approximately half of the hundred LTPs analyzed, confirming known ligands, while discovering new ones across most LTP families.
These strategies work best for people without existing heart disease, and under the guidance of a healthcare provider. High cholesterol may not cause noticeable symptoms, but it quietly raises the risk of heart attack and stroke over time. Statins are the gold standard treatment in Western medicine, but they come with side effects and long-term risks. Fortunately, many people can improve their low-density lipoprotein (LDL) and total cholesterol levels through diet, movement, and targeted supplements.
A Colorado endocrinologist helped spark a quiet revolution in weight care by changing how primary care clinics talk about - and treat - obesity. Instead of vague advice to "eat less and exercise more," a new system called PATHWEIGH gave patients a clear, judgment-free path to real medical support for weight management.
