Daily briefing: Vaccine-carrying mosquitoes could inoculate bats against rabies
Engineered mosquitoes carrying vaccines in saliva show promise for preventing rabies and Nipah virus transmission from bats to humans, though field effectiveness remains uncertain.
Structures of Marburgvirus glycoprotein and its complex with NPC1 receptor - Nature
Marburg virus causes 73% case fatality rate in humans with no licensed therapeutics or vaccines available, unlike Ebola virus which has approved treatments and vaccines despite lower mortality.
Scientists discover clue in viruses that reveal if they were lab-made
A new study analyzing seven viral outbreaks found no unusual genetic changes in Covid or most viruses before emergence, supporting a natural zoonotic origin rather than lab creation.
Capturing dynamic phage-pathogen coevolution by clinical surveillance - Nature
Phage-inducible chromosomal island-like elements (PLEs) in Vibrio cholerae provide defense against ICP1 phage predation, influencing pandemic strain evolution and disease severity through dynamic phage-bacteria interactions.
Large genome model: Open source AI trained on trillions of bases
Evo 2, an AI system trained on trillions of base pairs from all life domains, can identify genes, regulatory sequences, and splice sites in complex genomes including humans.
A membrane-bound nuclease directly cleaves phage DNA during genome injection - Nature
SNIPE is a membrane-bound nuclease defense system in bacteria that directly targets foreign nucleic acids to prevent phage infection through a novel mechanism distinct from established defense pathways.
The infection enigma: why some people die from typically harmless germs
Genetic mutations in immune-related genes cause inborn errors of immunity that make some people uniquely vulnerable to severe infections and immune disorders.
Why is India's Nipah virus outbreak spooking the world?
A Nipah virus outbreak in West Bengal has produced two confirmed health-worker cases; Nipah is a zoonotic, often deadly virus with person-to-person and foodborne transmission.
A broadly protective antibody targeting gammaherpesvirus gB - Nature
Cong Sun, Chu Xie, and Bing‑Zhen Cheng contributed equally; correspondence to Cong Sun, Zheng Liu, or Mu‑Sheng Zeng; affiliations include Sun Yat‑sen Cancer Center and SUSTech.