#ferroptosis

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#t-cell-immunity #dietary-fatty-acids #immune-homeostasis #lipid-metabolism #oestradiol #acute-kidney-injury
fromwww.nature.com
1 month ago

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

Ferroptosis, a major mechanism of non-apoptotic programmed cell death, critically regulates the homeostasis and functionality of peripheral CD4+ and CD8+ T cells. Here we demonstrate that in mouse, resistance of T cells to ferroptosis depends critically on the composition of standard rodent diets, and that dietary effects on ferroptosis have a crucial role in regulation of T cell homeostasis and immune responses.
Medicine
fromwww.nature.com
2 months ago

Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury

Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury Publisher Correction Open access Published: 21 January 2026 Wulf Tonnus orcid.org/0000-0002-9728-14131 na1, Francesca Maremonti2 na1, Shubhangi Gavali orcid.org/0000-0003-2876-14532 na1, Marlena Nastassja Schlecht orcid.org/0000-0001-8893-53261, Florian Gembardt2, Alexia Belavgeni orcid.org/0000-0001-6311-58583, Nadja Leinung2, Karolin Flade orcid.org/0009-0009-5449-28251, Natalie Bethe1,
Science
fromNature
4 months ago

Targeting FSP1 triggers ferroptosis in lung cancer - Nature

Ferroptosis is oxidative, lipid-peroxidation-driven cell death controlled by GPX4 and FSP1, with significant implications for cancer sensitivity and therapeutic targeting.
Cancer
fromNews Center
10 months ago

Targeting Tumor Metabolism to Trigger Cancer Cell Death - News Center

Researchers found a method to exploit treatment-resistant cancer cells' metabolic vulnerabilities leading to cell death through ferroptosis.
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